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2. Chew EY, Nutrition, Genes, and Age-Related Macular Degeneration: What Have We Learned from the Trials? Ophthalmologica. May 6, 2017. 3. The Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol. 2001 Oct; 1417-36 4. Product insert of Ocuvite® AREDS 2